Lyophilized QC Organisms
Cayman Chemical EZ-EndoxIfen 10mg
A potent ATP-uncompetitive inhibitor of MEK1 (Ki 0 13 nM in the presence of ATP) inhibits the proliferation of A375 BRAF(V600E) and HCT116 KRAS(G13D)-mutant cancer cell lines (EC50 7 and 42 nM respectively) upregulates pro-apoptotic BIM
Cayman Chemical EZ-DroloxIfen 10mg
An acylhydrazone with antifungal activity active against C. neoformans in vitro (MIC80 1 Ug/ml) inhibits the synthesis of glucosylceramide in C. neoformans but not J774 murine macrophages at 0.25 1 and 4 Ug/ml increases survival in a mouse model of C. neoformans infection at 1.2 mg/kg
Cayman Chemical EZ-IT-603 10mg
An isoquinoline alkaloid active against S. aureus P. aeruginosa and E. coli (MICs 250 125 and 125 Ug/ml respectively) P. falciparum and E. histolytica (IC50s 5.08 and 135 UM respectively) and a panel of seven phytopathogenic fungi (IC50s 15.2-42.4 Ug/ml)
Cayman Chemical EZ-4-hydroxy TamoxIfen 10mg
A cell-permeable porphyrin derivative that selectively binds STAT3 (Kd 880 nM) inhibits STAT3 dimerization via Src homology 2 (Sh2) domains (IC50 280 nM) preventing nuclear translocation and DNA binding
